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The use of beta-cyclodextrin as a pelletization agent in the extrusion/spheronization process
A Gazzaniga1, M E Sangalli, G Bruni
1Instituto Chimico Farmaceutico, Università di Milano, Italy. gazza@imiucca.csi.unimi.it
Drug Development and Industrial Pharmacy
|January 7, 1999
Summary
Beta-cyclodextrin is effective for creating pellets using extrusion/spheronization. High beta-cyclodextrin content, up to 90%, yields satisfactory pharmaceutical pellet products.
Area of Science:
- Pharmaceutical Technology
- Materials Science
Background:
- Beta-cyclodextrin is a versatile excipient in drug delivery.
- Extrusion/spheronization is a common method for pellet preparation.
Purpose of the Study:
- To evaluate beta-cyclodextrin as a primary component in pellet formulations.
- To determine the impact of formulation and processing on pellet characteristics.
Main Methods:
- Pellet preparation using extrusion/spheronization with varying beta-cyclodextrin concentrations.
- Physical characterization via sieve analysis.
- Technological assessment through friability testing.
Main Results:
- Pellets were successfully prepared with beta-cyclodextrin content up to 90% by weight.
- Sieve analysis and friability tests indicated satisfactory physical properties.
- Formulation and processing conditions influenced pellet quality.
Conclusions:
- Beta-cyclodextrin is a suitable excipient for producing high-quality pellets via extrusion/spheronization.
- The process is robust and adaptable for high-content beta-cyclodextrin formulations.