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Related Experiment Videos

Evaluation of hydrogel-based controlled-release niacin tablets

P Khullar1, R K Khar, S P Agarwal

  • 1Dabur Research Foundation, Ghaziabad, India.

Drug Development and Industrial Pharmacy
|January 7, 1999
PubMed
Summary

Controlled-release niacin tablets using guar gum showed decreased dissolution with higher gum content. Formulation stability was confirmed across various pH and moisture conditions, meeting controlled-release standards.

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Niacin is a vital B vitamin with therapeutic applications.
  • Controlled-release formulations aim to improve drug efficacy and patient compliance.
  • Guar gum is a natural polysaccharide explored for its potential in drug delivery systems.

Purpose of the Study:

  • To formulate matrix-based controlled-release niacin tablets using guar gum.
  • To investigate the impact of guar gum concentration on the in vitro dissolution profile.
  • To evaluate the stability of the formulation under varying environmental conditions.

Main Methods:

  • Tablets were formulated with varying concentrations of guar gum.
  • In vitro dissolution studies were conducted under different pH conditions.
  • The effect of granule moisture content on dissolution was assessed.

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  • Niacin tablets of different strengths (including 500 mg) were prepared and tested.

    • Main Results:

    • Increased guar gum content led to a decreased dissolution rate of niacin.
    • The dissolution profile remained largely unchanged across different pH levels.
    • Variations in granule moisture content did not significantly alter the dissolution characteristics.
    • The developed niacin tablets demonstrated consistent in vitro performance across different strengths.

    Conclusions:

    • Guar gum concentration is a critical factor influencing niacin release from matrix tablets.
    • The controlled-release niacin formulation exhibits good stability and predictable drug release.
    • The developed formulation meets established standards for controlled-release pharmaceutical products.