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Time of recombination in the Drosophila melanogaster oocyte: evidence from a temperature-sensitive

Proceedings of the National Academy of Sciences of the United States of America

|July 1, 1978

Abstract:

A temperature-sensitive recombination-deficient mutant, rec-126, has been isolated that permits high frequencies of recombination at the permissive temperature (25 degrees) but greatly decreases recombination at the restrictive temperature (31 degrees). The sensitive period for response of female germ cells carrying this mutant to the restrictive temperature has been defined. Sensitivity begins very close to the time the oocyte enters premeiotic interphase and initiates DNA synthesis; it continues for the duration of premeiotic-S; and it terminates with the completion of S. This time span precisely coincides with the sensitive period for enhancement of recombination by heat in the normal genome and is further characterized by the presence of the synaptonemal complex. These results provide compelling evidence for identifying premeiotic-S as the time of meiotic recombination.

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Articles linked to this work by shared authors, journal, and citation graph.

The meiotic process and aneuploidy.

Basic life sciences·1985

Time of Recombination in the DROSOPHILA MELANOGASTER Oocyte. III. Selection and Characterization of Temperature-Sensitive and -Insensitive, Recombination-Deficient Alleles in Drosophila.

Genetics·1984

Synaptonemal complexes at premeiotic interphase in the mouse spermatocyte.

Proceedings of the National Academy of Sciences of the United States of America·1980

Time of recombination in the Drosophila melanogaster oocyte. II. Electron microscopic and genetic studies of a temperature-sensitive recombination mutant.

Chromosoma·1980

Origin of meiotic nondisjunction in Drosophila females.

Environmental health perspectives·1979

A Comparison of Heat and Interchromosomal Effects on Recombination and Interference in DROSOPHILA MELANOGASTER.

Genetics·1978

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