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Buspirone use for smoking cessation

P Farid1, M A Abate

  • 1School of Pharmacy, West Virginia University, Morgantown, USA.

The Annals of Pharmacotherapy
|January 7, 1999
PubMed
Summary
This summary is machine-generated.

Buspirone

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Area of Science:

  • Pharmacology
  • Addiction Medicine
  • Clinical Trials

Background:

  • Inconsistent results exist regarding buspirone's effectiveness for smoking cessation.
  • Previous studies show wide ranges in abstinence rates for both buspirone and placebo groups.
  • Limited evidence exists for buspirone's efficacy in reducing nicotine withdrawal symptoms.

Purpose of the Study:

  • To evaluate buspirone's efficacy in smoking cessation and reducing nicotine withdrawal.
  • To investigate buspirone's potential role in managing anxiety associated with smoking cessation.
  • To compare buspirone with other smoking cessation therapies like bupropion.

Main Methods:

  • A placebo-controlled, randomized trial is proposed.
  • Inclusion criteria: large patient numbers, high buspirone doses (30-60 mg/d), strict abstinence criteria, long-term follow-up.
  • Focus on smokers with general anxiety or anxiety during prior quit attempts.

Main Results:

  • Current research shows conflicting outcomes for buspirone in smoking cessation.
  • Recent studies have failed to demonstrate buspirone's efficacy for quitting or withdrawal relief.
  • Further research is needed to clarify buspirone's role and optimal usage.

Conclusions:

  • Buspirone's efficacy in smoking cessation remains uncertain due to contradictory findings.
  • High-quality trials are necessary to determine buspirone's effectiveness, especially for anxious smokers.
  • Buspirone could be a potential alternative for individuals who do not respond to or tolerate nicotine replacement therapy.