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Updated: Aug 14, 2026
Mouse Model of Intraluminal MCAO: Cerebral Infarct Evaluation by Cresyl Violet Staining
Published on: November 6, 2012
Role of superoxide dismutase in ischemic brain injury: a study using SOD-1 transgenic mice
H Kinouchi1, H Kamii, S Mikawa
1Department of Neurosurgery, Tohoku University School of Medicine, Sendai, Japan.
Abstract:
1. Nitric oxide radicals (NO) play an important role in the pathophysiology of focal cerebral ischemia. 2. Vascular NO can reduce ischemic brain injury by increasing CBF, whereas neuronal NO may mediate neurotoxicity following brain ischemia, mainly by its reaction with superoxide to generate peroxynitrite. 3. These findings could contribute to a strategy for the treatment of cerebral ischemia.
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