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Lung deposition of budesonide from turbuhaler in asthmatic children
J H Wildhaber1, S G Devadason, J M Wilson
1Department of Respiratory Medicine, Princess Margaret Hospital for Children, Subiaco, WA, Australia. hannesw@cyllene.uwa.edu.au
Insights
Lung deposition of budesonide in asthmatic children increases with age and inspiratory flow. Even younger children achieve satisfactory lung deposition with the Turbuhaler dry powder inhaler.
Area of Science:
- Pediatric Pulmonology
- Respiratory Drug Delivery
- Medical Imaging
Background:
- Asthma management in children relies on effective inhaled corticosteroid delivery.
- The Turbuhaler is a common dry powder inhaler (DPI) used for delivering budesonide.
- Understanding factors influencing lung deposition is crucial for optimizing therapy.
Purpose of the Study:
- To investigate the impact of age on the lung deposition of radiolabeled budesonide in children with asthma.
- To assess the relationship between peak inspiratory flow and budesonide lung deposition.
Main Methods:
- 23 children (6-16 years) with stable asthma inhaled 99mTc-labeled budesonide via Turbuhaler.
- Gamma camera imaging was used to quantify body and lung deposition.
- Peak inspiratory flow (PIF) was measured during inhalation.
Main Results:
- Mean total lung deposition was 29.1% of the metered dose.
- Lung deposition showed a significant positive correlation with age, height, and PIF.
- Mean PIF ranged from 45 to 76 L/min.
Conclusions:
- Lung deposition of budesonide from a DPI is age-dependent in pediatric asthma.
- Despite age-related variations, lung deposition is generally satisfactory in children, including younger ones with lower PIF.
Unlabelled:
The aim of our study was to evaluate the effect of age on lung deposition of radiolabelled budesonide, delivered as a dry powder via Turbuhaler to asthmatic children. A group of 23 asthmatic children, aged 6 to 16 years, with relatively stable asthma inhaled 99mTc-labelled budesonide from a dry powder inhaler (Turbuhaler). Body and lung deposition was assessed using a gamma camera. The mean (range) median peak inspiratory flow during inhalation was 65 1 x min(-1) (45 to 76 1 x min(-1)). Mean (range) total lung deposition of 99mTc-labelled budesonide, expressed as a percentage of the metered dose, was 29.1% (15.6-47.2%) and was positively and significantly correlated with age, height and peak inspiratory flow.
Conclusion:
Total lung deposition of radiolabelled budesonide from a dry powder inhaler (Turbuhaler), is age dependent in children with moderate asthma. However, lung deposition is still satisfactory, even in younger children with lower peak inspiratory flows.