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Evaluation of febrile children with petechial rashes: is there consensus among pediatricians?
D G Nelson1, J Leake, J Bradley
1Department of Pediatrics, Hasbro Children's Hospital, Brown University School of Medicine, Providence, RI, USA.
Insights
Pediatricians show varied approaches to evaluating febrile children with petechial rashes. While differences exist among specialists, most practice variations in managing these cases diminish with experience and setting adjustments.
Area of Science:
- Pediatric infectious diseases
- Clinical practice variations
- Febrile illness management
Background:
- Febrile children with petechial rashes present a diagnostic challenge due to potential for serious infections like Neisseria meningitidis.
- Current evaluation and management strategies for these children are subject to debate.
Purpose of the Study:
- To identify and compare practice trends in evaluating and managing non-toxic-appearing febrile children with petechial rashes across different pediatric subspecialties.
- To understand how factors like clinical presentation and laboratory results influence physician decision-making.
Main Methods:
- A survey was distributed to 416 pediatricians across general pediatrics (community and academic), emergency medicine, and infectious diseases.
- Respondents evaluated four hypothetical cases of febrile children with petechial rashes, varying in age, appearance, and lab results.
- Logistic regression analysis was used to compare specialty group responses, controlling for practice setting, population size, and physician experience.
Main Results:
- Significant variations were observed in blood culture rates and hospital admissions for younger children, particularly between emergency medicine and general pediatrics groups.
- For older children with clear sources for petechiae, most physicians opted against lumbar puncture or admission, though blood culture use varied.
- Regression analysis indicated that practice setting, population size, and physician experience accounted for most observed differences between groups.
Conclusions:
- Substantial differences exist in how pediatricians evaluate young febrile children with petechial rashes.
- While some inter-specialty variations in practice are noted, these tend to decrease when accounting for practice environment and physician experience.
Background:
The evaluation of febrile children with petechial rashes evokes controversy. Although many of these children have viral infections, on occasion such patients may be infected with Neisseria meningitidis.
Objective:
To investigate differences in practice trends for the evaluation and management of non-toxic-appearing febrile children with petechial rashes among pediatric specialty groups.
Methods:
We surveyed 833 pediatricians in 4 specialties [community (CGP) and academic (AGP) general pediatrics, emergency medicine (EM) and infectious diseases] regarding 4 hypothetical non-toxic-appearing febrile children ages 1, 2, 5 and 7 years. The patients differed with regard to clinical appearance, distribution of petechiae and complete blood count results. We compared specialty group responses, adjusting for practice setting, population size and years in practice using multiple logistic regression analysis.
Results:
The survey was completed and returned by 416 (50%) pediatricians. There was substantial variation in the evaluation of the 2 younger febrile children without clear sources for their petechiae. For the 1-year-old the overall blood culture (BCx) rate was 82%, with the EM group (91%) more often requesting BCx than either the CGP (76%) or AGP (73%, P=0.001) groups. The overall hospital admission rate was 31%, with CGP less often requesting admission than infectious disease pediatricians (22% vs. 40%, P=0.007). In the regression analysis the only significant difference between groups was in BCx rate between the EM and AGP groups. For the 2-year-old the overall rate of BCx was 95%, lumbar puncture was 41% and admission was 44%, with no significant differences among groups. For the scenarios involving the 2 older febrile children with sources for their petechiae, the majority of respondents chose neither lumbar puncture nor admission. There was disagreement regarding BCx, both within and between groups, although most of the between group differences did not persist in the regression analysis.
Conclusions:
There are substantial differences among pediatricians in the evaluation of young non-toxic-appearing febrile children with petechial rashes. Although there are some differences between pediatric subspecialties, most of these differences do not persist after adjusting for practice setting, population size and physician experience.
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