Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antigen-presenting cells in experimental autoimmune uveoretinitis

S Ishimoto1, J Zhang, V K Gullapalli

  • 1Doheny Eye Institute and the Department of Ophthalmology, University of Southern California School of Medicine, California, 90033, USA.

Experimental Eye Research
|January 8, 1999
PubMed
Summary

Bone marrow-derived cells in the retina and pineal gland present S-antigen to T cells, initiating uveoretinitis and pinealitis. These antigen-presenting cells are crucial for initiating autoimmune eye and pineal gland inflammation.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hematopoietically derived retinal perivascular microglia initiate uveoretinitis in experimental autoimmune uveitis.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2000
Same author

Retinal microglia differentially express phenotypic markers of antigen-presenting cells in vitro.

Investigative ophthalmology & visual science·1999
Same author

Expression of major histocompatibility complex molecules in rodent retina. Immunohistochemical study.

Investigative ophthalmology & visual science·1997
Same author

In vivo clonotypic regulation of human myelin basic protein-reactive T cells by T cell vaccination.

Journal of immunology (Baltimore, Md. : 1950)·1995
Same author

Superantigen reactivity of gamma delta T cell clones isolated from patients with multiple sclerosis and controls.

Cellular immunology·1995
Same author

Tissue distribution of cocaine methyl esterase and ethyl transferase activities: correlation with carboxylesterase protein.

The Journal of pharmacology and experimental therapeutics·1995

Area of Science:

  • Immunology
  • Ophthalmology
  • Neuroscience

Background:

  • Uveoretinitis and pinealitis are inflammatory conditions affecting the eye and pineal gland.
  • Antigen-presenting cells (APCs) play a critical role in initiating immune responses.
  • Identifying APCs in the retina and pineal gland is crucial for understanding these diseases.

Purpose of the Study:

  • To identify antigen-presenting cells in the retina and pineal gland.
  • To investigate the role of bone marrow-derived cells in initiating uveoretinitis and pinealitis.

Main Methods:

  • Chimeric rats were generated by bone marrow transplantation.
  • Adoptive transfer of S-antigen-specific T cells was performed.
  • Immunohistochemical analysis using an antibody against Lewis specific MHC class II molecules (OX-3) was conducted.

Related Experiment Videos

Main Results:

  • Uveoretinitis and pinealitis developed in chimeric rats and Lewis/F1 hybrid rats, but not in BN rats.
  • OX-3-positive cells with dendritic morphology were found in the retina and pineal gland of affected animals.
  • These positive cells were bone marrow-derived, indicating their role as APCs.

Conclusions:

  • Bone marrow-derived cells in the retina and pineal gland function as APCs.
  • These APCs present S-antigen to T cells, triggering autoimmune inflammation.
  • This finding provides insight into the pathogenesis of uveoretinitis and pinealitis.