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Related Experiment Videos

Bioavailability of ferulic acid

L C Bourne1, C Rice-Evans

  • 1International Antioxidant Research Centre, Guy's King's College, London, United Kingdom.

Biochemical and Biophysical Research Communications
|January 8, 1999
PubMed
Summary

This study shows that ferulic acid, found in foods like tomatoes, is absorbed by the body. Urinary excretion indicates that 11-25% of ingested ferulic acid is recovered, with peak excretion around 7 hours.

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Area of Science:

  • Nutritional Science
  • Pharmacokinetics
  • Food Chemistry

Background:

  • Flavonoids are known antioxidants, but hydroxycinnamates' bioavailability is less understood.
  • Hydroxycinnamates are prevalent in fruits, vegetables, beverages, and grains.
  • Understanding in vivo absorption of dietary hydroxycinnamates is crucial.

Purpose of the Study:

  • To investigate the bioavailability of ferulic acid in humans.
  • To assess ferulic acid absorption from tomato consumption.
  • To monitor urinary excretion patterns relative to intake.

Main Methods:

  • Human pharmacokinetic study.
  • Monitoring urinary excretion of ferulic acid and its metabolites.
  • Quantifying ferulic acid intake from tomatoes.

Main Results:

  • Peak urinary excretion of ferulic acid occurred approximately 7 hours post-ingestion.
  • Urinary recovery of total free ferulic acid and feruloyl glucuronide ranged from 11% to 25% of the ingested amount.
  • Demonstrated in vivo absorption of ferulic acid from dietary sources.

Conclusions:

  • Ferulic acid is bioavailable from tomato consumption in humans.
  • Urinary excretion provides a viable method for assessing ferulic acid bioavailability.
  • Further research can explore hydroxycinnamate absorption from various dietary sources.

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