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Protein O-mannosylation

S Strahl-Bolsinger1, M Gentzsch, W Tanner

  • 1Lehrstuhl für Zellbiologie und Pflanzenphysiologie, Universität Regensburg, 93040 Regensburg, Germany.

Biochimica Et Biophysica Acta
|January 8, 1999
PubMed
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Protein O-mannosylation, a process involving protein O-mannosyltransferases (PMTs), is crucial for fungal cell wall integrity and secretion. This conserved pathway is also found in higher eukaryotes.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Mycology

Background:

  • Protein O-mannosylation initiates in the endoplasmic reticulum, transferring mannose to seryl/threonyl residues of secretory proteins.
  • This glycosylation is catalyzed by protein O-mannosyltransferases (PMTs), first identified in Saccharomyces cerevisiae.
  • The PMT gene family is evolutionarily conserved and essential for various physiological processes.

Purpose of the Study:

  • To discuss the biogenesis of O-linked carbohydrate chains in fungi, focusing on the PMT gene family.
  • To summarize research on the role of protein O-mannosylation in fungal physiology using pmt mutants.
  • To report and discuss the presence of PMT orthologs in higher eukaryotes.

Main Methods:

  • Characterization of the protein O-mannosyltransferase (PMT) gene family.

Related Experiment Videos

  • Analysis of pmt mutants in Saccharomyces cerevisiae and Candida albicans.
  • Bioinformatic identification and comparison of PMT orthologs across different eukaryotic species.

    • Main Results:

    • Protein O-mannosylation significantly impacts protein secretion, cell wall integrity, and budding in fungi.
    • The PMT gene family is essential for these vital fungal processes.
    • PMT orthologs have been identified in diverse higher eukaryotes, including plants, insects, and mammals.

    Conclusions:

    • Protein O-mannosylation is a fundamental and conserved biological process with critical roles in fungal cell biology.
    • The study of PMTs in fungi provides insights into conserved eukaryotic cellular mechanisms.
    • Further investigation into PMT function in higher eukaryotes is warranted.