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Updated: Sep 21, 2026

A Simple Bioassay for the Evaluation of Vascular Endothelial Growth Factors
Published on: March 15, 2016
Identification and characterization of a new splicing variant of vascular endothelial growth factor: VEGF183
1Department of Pharmacology, University of Minnesota, 3-249 Millard Hall, 435 Delaware St. S.E., Minneapolis, MN 55455, USA.
Abstract:
We report the discovery of a new splicing variant of vascular endothelial growth factor named VEGF183. It is six amino acids shorter than its closest relative, VEGF189, due to the utilization of a conserved alternate splicing donor site within exon 6a. Highly expressed in heart tissue, VEGF183 is detected in transiently transfected COS cells as 28-32-kDa monomers under reduced condition, and 46-kDa dimers under non-reduced condition - the functional unit for all VEGF isoforms.
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