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Adhesion molecules in inflammatory diseases

R González-Amaro1, F Díaz-González, F Sánchez-Madrid

  • 1Hospital Universitario de la Princesa, Universidad Autónoma de Madrid, Spain.

Drugs
|January 8, 1999
PubMed
Summary

Cell adhesion molecules (CAM) are crucial for leukocyte migration during inflammation. Targeting CAM offers a promising therapeutic strategy for inflammatory diseases, with new antiadhesion treatments under development.

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Area of Science:

  • Immunology
  • Cell Biology
  • Biochemistry

Background:

  • Cell adhesion molecules (CAM) play a critical role in the inflammatory response.
  • Leukocyte migration from blood to inflammatory sites involves selectins, integrins, and immunoglobulin (Ig) superfamily CAM.
  • Endothelial cell (EC) activation upregulates CAM expression, initiating leukocyte-EC interactions.

Purpose of the Study:

  • To elucidate the role of CAM in leukocyte migration during inflammation.
  • To highlight the therapeutic potential of targeting CAM in inflammatory diseases.

Main Methods:

  • Review of literature on CAM function in leukocyte adhesion and migration.
  • Analysis of molecular mechanisms underlying CAM-mediated interactions.
  • Overview of current and developing therapeutic strategies targeting CAM.

Main Results:

  • Selectins mediate initial leukocyte rolling on activated endothelium.
  • Integrins and Ig superfamily CAM facilitate firm adhesion and extravasation.
  • Leukocyte activation occurs during rolling via CAM and chemokine receptor signaling.

Conclusions:

  • CAM blockade is a viable therapeutic target for inflammatory conditions.
  • Various antiadhesion therapies, including monoclonal antibodies and small molecules, are under development.

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