Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Local substances regulating cochlear blood flow

K Konishi1, H Yamane, H Iguchi

  • 1Department of Otolaryngology, Osaka City University Medical School, Japan.

Acta Oto-Laryngologica. Supplementum
|January 8, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Smallest Optical Gap for Pt(II)-Pt(IV) Mixed-Valence Pt-Cl and Pt-Br Chain Complexes Achieved by Using a Multiple-Hydrogen-Bond Approach.

Inorganic chemistry·2018
Same author

Electronic structure of AlCrN films investigated using various photoelectron spectroscopies and ab initio calculations.

Journal of physics. Condensed matter : an Institute of Physics journal·2017
Same author

Randomised phase II trial of irinotecan plus S-1 in patients with gemcitabine-refractory pancreatic cancer.

British journal of cancer·2017
Same author

Diagnosis and treatment of bone metastasis: comprehensive guideline of the Japanese Society of Medical Oncology, Japanese Orthopedic Association, Japanese Urological Association, and Japanese Society for Radiation Oncology.

ESMO open·2016
Same author

Gibberellins and Antheridiogens in Prothallia and Sporophytes of Anemia phyllitidis.

Bioscience, biotechnology, and biochemistry·2016
Same author

Identification of Gibberellins and 9,15-Cyclogibberellins in Developing Apple Seeds.

Bioscience, biotechnology, and biochemistry·2016

Cochlear lateral wall blood flow regulation primarily occurs in the spiral ligament via local substances. Strial capillaries are not significantly controlled by pericytes, suggesting distinct regulatory mechanisms.

Area of Science:

  • Oto-rhino-laryngology
  • Vascular Biology
  • Cellular Physiology

Background:

  • Cochlear blood flow is crucial for hearing function.
  • Mechanisms regulating cochlear lateral wall blood flow are not fully understood.
  • Vascular cells and signaling molecules play key roles in microcirculation.

Purpose of the Study:

  • To investigate the regulation of cochlear lateral wall blood flow in rats.
  • To identify the cellular and molecular players involved in regulating blood flow in the spiral ligament and stria vascularis.
  • To differentiate the regulatory mechanisms between spiral ligament vessels and strial capillaries.

Main Methods:

  • Histochemistry
  • Immunohistochemistry
  • Transmission electron microscopy

Related Experiment Videos

Main Results:

  • Tropomyosin (TM), a contractile protein, was localized in pericytes of spiral ligament vessels but scarce around strial capillaries.
  • Prostaglandin I2 synthase (PGI2S), an enzyme producing the vasodilator PGI2, was present in the endothelium of spiral ligament vessels but not significantly around strial capillaries.
  • Endothelial nitric oxide synthase (eNOS) was found in the endothelium of both spiral ligament vessels and strial capillaries.

Conclusions:

  • Cochlear lateral wall blood flow is mainly regulated in the spiral ligament by locally produced vasoactive substances.
  • Strial blood flow regulation appears independent of pericyte-mediated capillary constriction or dilation.
  • Distinct microvascular regulatory mechanisms exist between the spiral ligament and stria vascularis in the cochlea.