Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pharmacological comparison between enflurane and halothane]

J Kitagawa, K Iwatsubo, Y Shigenaga

    Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
    |March 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dentinal tubules occluded by bioactive glass-containing toothpaste exhibit high resistance toward acidic soft drink challenge.

    Australian dental journal·2016
    Same author

    Terahertz conductivity of localized photoinduced carriers in a Mott insulator YTiO(3) at low excitation density, contrasted with the metallic nature in a band semiconductor Si.

    Journal of physics. Condensed matter : an Institute of Physics journal·2011
    Same author

    Ethanol dissociates thiopental and GABA-receptor interaction.

    Neurochemistry international·2010
    Same author

    Selective enhancement in striatal [(3)H]nitrendipine binding following chronic treatment with morphine.

    Neurochemistry international·2010
    Same author

    Effect of thiopental on hippocampal GABA receptors in rat brain.

    Neurochemistry international·2010
    Same author

    Bioequivalence study of two limaprost alfadex 5 microg tablets in healthy subjects: moisture-resistant tablet (dextran formulation) versus standard tablet (lactose formulation).

    International journal of clinical pharmacology and therapeutics·2008

    Enflurane (E) and halothane (H) demonstrate distinct pharmacological profiles. Enflurane exhibits faster clearance and altered central nervous system effects compared to halothane.

    Area of Science:

    • Anesthesiology
    • Pharmacology
    • Neuroscience

    Background:

    • Inhalational anesthetics like enflurane and halothane are widely used.
    • Understanding their comparative pharmacological properties is crucial for safe clinical application.

    Purpose of the Study:

    • To investigate and compare the general pharmacological properties of enflurane and halothane.
    • To elucidate differences in their effects on various physiological systems.

    Main Methods:

    • Pharmacokinetic analysis including blood concentration, uptake velocity, and half-life.
    • Assessment of neuromuscular junction activity and muscle tension.
    • Evaluation of central nervous system effects, including reflexes, anticonvulsant activity, and electroencephalogram (EEG) changes.

    Related Experiment Videos

    Main Results:

    • Enflurane displayed lower maximum blood concentration, slower uptake, and a shorter half-life than halothane.
    • Both agents reduced uterine and intestinal muscle tension, with halothane more potently inhibiting polysynaptic reflexes.
    • Enflurane demonstrated greater inhibition of tonic-clonic convulsions and altered EEG patterns differently than halothane.

    Conclusions:

    • Enflurane and halothane possess unique pharmacokinetic and pharmacodynamic properties.
    • Differences in their effects on the central nervous system and neuromuscular function warrant consideration in anesthetic practice.