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Prognosis of Japanese encephalitis: a multivariate analysis
U K Misra1, J Kalita, M Srivastava
1Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India. ukmisra@sgpgi.ren.nic.in
Journal of the Neurological Sciences
|January 8, 1999
Summary
Age, Glasgow coma scale, and reflex changes are key predictors for determining Japanese encephalitis (JE) patient outcomes. These factors help forecast recovery, aiding in clinical management and prognosis.
Area of Science:
- Neurology
- Infectious Diseases
- Clinical Neurophysiology
Background:
- Japanese encephalitis (JE) poses a significant neurological threat, necessitating accurate prognostic indicators.
- Understanding factors influencing JE patient outcomes is crucial for effective clinical management.
Purpose of the Study:
- To identify clinical, laboratory, neurophysiological, and radiological predictors of long-term outcomes in Japanese encephalitis patients.
- To evaluate the role of various parameters in the prognosis of JE.
Main Methods:
- Prospective evaluation of 28 Japanese encephalitis patients (age 2-54 years).
- Assessment of clinical, laboratory (CSF, serum), neurophysiological (EEG, EMG, evoked potentials), and radiological parameters.
- Stepwise multivariate logistic regression analysis to determine outcome predictors over a six-month period.
Main Results:
- Outcomes at six months included death (4), poor recovery (7), partial recovery (10), and complete recovery (7).
- The most significant predictors of outcome were patient age, Glasgow coma scale score, and reflex changes.
- Clinical neurophysiological and radiological data showed less predictive power compared to key clinical factors.
Conclusions:
- Age, Glasgow coma scale, and reflex changes are the strongest predictors for Japanese encephalitis prognosis.
- These clinical parameters can guide therapeutic strategies and patient management for better outcomes.