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Astroglia-microvessel relationship in the developing human telencephalon

D Virgintino1, E Maiorano, M Errede

  • 1Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy. virgintino@histology-uniba.it

The International Journal of Developmental Biology
|January 8, 1999
PubMed
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Immature astroglia cells interact with developing brain microvessels, influencing their pattern and maturation during human telencephalon development. This study highlights the crucial astroglia-microvessel relationship in early neurodevelopment.

Area of Science:

  • Developmental Neuroscience
  • Neurobiology
  • Histology

Background:

  • The developing human telencephalon undergoes complex morphogenesis, involving the intricate formation of neural tissues and their vascular supply.
  • Understanding the relationship between developing glial cells and microvessels is crucial for comprehending brain development and potential disorders.

Purpose of the Study:

  • To investigate the relationship between immature astroglia and microvessels in the human telencephalon at 12 and 18 weeks of gestation.
  • To elucidate the role of astroglia in the early establishment, growth, and maturation of neural microvessels.

Main Methods:

  • Immunohistochemistry was used to examine telencephalon tissue from human fetuses (12 and 18 weeks old).
  • Antibodies against cytoskeletal proteins vimentin (VIM) and glial fibrillary acidic protein (GFAP) were used for astroglia.

Related Experiment Videos

  • Antibodies for blood-brain barrier (BBB)-specific glucose transporter GLUT1, laminin (LM), and tenascin-C (TN-C) were used for microvessels and extracellular matrix.

    • Main Results:

    • Immature astroglia (radial glia, astroblasts) and astrocytes showed close associations with radial and periventricular microvessels.
    • Microvessels were positive for GLUT1 and lined by LM, indicating blood-brain barrier characteristics.
    • A tenascin-C-rich extracellular matrix was observed around vascular plexuses and newly growing microvessels, suggesting glia-derived influence.

    Conclusions:

    • Immature astroglia cells play a significant role in establishing the distribution pattern of neural microvessels during telencephalon morphogenesis.
    • Astroglia contribute to the growth and maturation of the brain's microvasculature in early human development.