[Studies of gamma-oryzanol (1). Effects on stress-induced ulcer]

In clinical trials, it is well known that gamma-oryzanol is effective against the syndromes of autonomic nervous unbalance and climacteric disorders. The authors studied the action of gamma-oryzanol on restraint, water-immersion stress ulcer under various conditions in rats. The drug, given 1 to 100 mg/kg s.c. daily for five days, reduced the ulcer index dose-dependently, and slightly prevented the rate of increase in serum level of 11-OHCS. These effects were observed in adrenalectomized as well as sham operated rats. It is likely that the antiulcerogenic action of gamma-oryzanol is due to participation of the autonomic nervous system, but not the hypophyseoadrenal axis.