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Related Experiment Videos

Sequencing microbial genomes--what will it do for microbiology?

P J Jenks1

  • 1Unité de Pathogénie Bactérienne des Muqueuses, Institut Pasteur, Paris, France.

Journal of Medical Microbiology
|January 8, 1999
PubMed
Summary
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The first microbial genome sequencing in 1995 opened doors for sequencing more pathogens. Advances in large-scale genetic analysis will revolutionize the diagnosis and treatment of infectious diseases.

Area of Science:

  • Microbiology
  • Genomics
  • Bioinformatics

Background:

  • The first free-living organism genome, Haemophilus influenzae, was sequenced in 1995.
  • Numerous human pathogen genomes are being sequenced, with many expected by the year 2000.
  • Significant progress in large-scale microbial genetic analysis techniques is occurring concurrently.

Purpose of the Study:

  • To highlight the impact of microbial genome sequencing and large-scale genetic analysis.
  • To discuss the potential for identifying new virulence factors and therapeutic targets.
  • To explore the future of diagnosing and combating infectious diseases.

Main Methods:

  • Genome sequencing projects.
  • Development of techniques for large-scale genetic analysis of microorganisms.

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Main Results:

  • The sequencing of Haemophilus influenzae in 1995.
  • Anticipation of sequenced genomes for numerous human pathogens by the millennium.
  • Advancements in technologies for studying microbial genetic complements.

Conclusions:

  • Microbial genomics and large-scale genetic analysis will deepen understanding of pathogenesis.
  • New virulence determinants will be identified as targets for diagnostics, antimicrobials, and vaccines.
  • The practice of microbiology and the management of infectious diseases will be transformed.