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Regionalized sensorimotor plasticity after hemispherectomy fMRI evaluation

C J Graveline1, D J Mikulis, A P Crawley

  • 1Department of Rehabilitation Services, The Hospital for Sick Children and Bloorview Epilepsy Program, University of Toronto, Ontario, Canada.

Pediatric Neurology
|January 8, 1999
PubMed
Summary

Children can regain motor and sensory functions after hemisphere removal, with the remaining brain adapting. This brain plasticity shows regionalization, highlighting functional reorganization in associative areas.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Cognitive Neuroscience

Background:

  • Children with extensive brain damage, such as the removal of an entire cerebral hemisphere, often face significant functional deficits.
  • Understanding the brain's capacity for reorganization (plasticity) is crucial for developing effective rehabilitation strategies.

Observation:

  • This study investigated functional recovery in children who underwent hemispherectomy.
  • Researchers examined the transfer of motor and sensory functions to the remaining cerebral hemisphere.

Findings:

  • Motor and sensory functions were successfully transferred to the intact hemisphere following hemispherectomy.
  • The remaining hemisphere utilized associative motor and sensory areas, not the typical primary regions, for these newly acquired functions.

Related Experiment Videos

  • This indicates a regionalization of brain plasticity, where specific cortical areas adapt for new roles.

    • Implications:

    • The findings suggest that the brain exhibits remarkable regionalized plasticity, even after drastic surgical intervention.
    • Functional magnetic resonance imaging (fMRI) is validated as a valuable tool for assessing brain plasticity and functional reorganization.
    • This research opens avenues for targeted therapies aimed at optimizing functional recovery in pediatric neurological conditions.