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Related Experiment Videos

Neonatal adrenal congestion: a sonographic-pathologic correlation

B Z Koplewitz1, A Daneman, E Cutz

  • 1Department of Diagnostic Imaging, Hospital for Sick Children and the University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8 Canada.

Pediatric Radiology
|January 9, 1999
PubMed
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Neonatal adrenal gland enlargement and abnormal echogenicity on ultrasound may indicate perinatal stress. These findings, often linked to poor outcomes, highlight the importance of adrenal assessment in critically ill newborns.

Area of Science:

  • Neonatal Medicine
  • Pediatric Radiology
  • Pathology

Background:

  • Diffuse adrenal gland enlargement and abnormal echogenicity are observed in neonates.
  • These findings can be associated with conditions like perinatal asphyxia and mechanical ventilation.
  • The clinical significance and pathological basis require further elucidation.

Purpose of the Study:

  • To correlate sonographic findings of adrenal gland abnormalities with clinical and pathological data in neonates.
  • To investigate the association between these adrenal changes and perinatal stress factors.
  • To understand the prognostic implications of sonographically detected adrenal abnormalities.

Main Methods:

  • Retrospective review of clinical, sonographic, and pathological data from eight neonates.

Related Experiment Videos

  • Detailed sonographic assessment of adrenal gland size, echogenicity, and morphology.
  • Histopathological examination of adrenal glands in autopsied cases.

    • Main Results:

    • Sonographic findings included enlarged adrenal glands with smooth surfaces and loss of the central echogenic stripe.
    • Four neonates experienced perinatal asphyxia; two required mechanical ventilation.
    • Histology revealed diffuse sinusoidal congestion in all five autopsied cases.
    • Poor outcomes were noted, including death in six neonates and severe developmental delay in one.

    Conclusions:

    • Sonographic adrenal gland abnormalities are part of the spectrum of changes seen in neonatal asphyxia and perinatal stress.
    • These findings may indicate a poor prognosis, likely due to associated sequelae of the underlying condition.
    • Adrenal gland assessment via ultrasound is valuable in evaluating critically ill neonates.