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Related Experiment Videos

New antidiabetic compounds, mangiferin and its glucoside

H Ichiki1, T Miura, M Kubo

  • 1Tsumura Central Research Laboratories, Tsumura and Co., Ibaraki, Japan.

Biological & Pharmaceutical Bulletin
|January 9, 1999
PubMed
Summary

Mangiferin (MF) and its glucosides (MG) effectively lower blood glucose and improve insulin sensitivity in diabetic mice. These compounds show promise for treating non-insulin-dependent diabetes mellitus (NIDDM).

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The Mechanism of Binding of Glucoamylase I from Aspergillus awamori var. kawachi to Cyclodextrins and Raw Starch.

Bioscience, biotechnology, and biochemistry·2016

Area of Science:

  • Pharmacology and Traditional Medicine
  • Metabolic Disorders Research

Background:

  • Non-insulin-dependent diabetes mellitus (NIDDM) is a significant global health concern.
  • Anemarrhena asphodeloides Bunge rhizome is a traditional herbal medicine.
  • Mangiferin (MF) and its glucosides (MG) are bioactive compounds found in this rhizome.

Purpose of the Study:

  • To evaluate the antidiabetic activity of Mangiferin (MF) and its glucosides (MG).
  • To investigate the effects of MF and MG on blood glucose and insulin levels in a diabetic animal model.

Main Methods:

  • Isolation of Mangiferin (MF) and mangiferin-7-O-beta-glucoside (MG) from Anemarrhena asphodeloides Bunge rhizome.
  • Administration of MF and MG to KK-Ay mice, an established animal model for NIDDM.
  • Monitoring of blood glucose levels in both diabetic (KK-Ay) and normal mice.

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  • Assessment of hyperinsulinemia in KK-Ay mice.

    • Main Results:

    • Oral administration of MF and MG significantly lowered blood glucose levels in KK-Ay mice.
    • No significant effect on blood glucose was observed in normal mice, suggesting specific action in diabetes.
    • Both MF and MG demonstrated an improvement in hyperinsulinemia among KK-Ay mice.

    Conclusions:

    • Mangiferin (MF) and its glucosides (MG) possess significant antidiabetic properties.
    • The compounds appear to exert their therapeutic effects by enhancing insulin sensitivity.
    • MF and MG are potential therapeutic agents for managing NIDDM.