[A facilitated technique for donor hepatectomy: experimental study in the pig]

Area of Science:

• Surgical techniques in organ transplantation
• Comparative analysis of organ procurement methods
• Histological and functional assessment of liver grafts

Context:

• Traditional liver procurement involves in situ portal perfusion, which can be time-consuming and limits simultaneous harvesting of other organs.
• Porcine models are crucial for advancing transplantation research due to physiological similarities with humans.
• Evaluating graft viability without extensive perfusion is essential for optimizing organ utilization.

Purpose:

• To describe a facilitated technique for porcine donor hepatectomy without in situ portal perfusion.
• To compare the viability and early function of liver grafts procured with and without in situ portal perfusion.
• To assess the feasibility of simultaneous harvesting of other abdominal organs during this modified hepatectomy procedure.

Summary:

• A simplified porcine donor hepatectomy technique was developed, omitting in situ portal perfusion.
• This method allows for concurrent procurement of organs from the superior mesenteric system.
• Histological evaluation and early graft function (2 hours post-reperfusion) showed no significant differences between grafts procured with or without in situ portal perfusion.

Impact:

• This facilitated technique may streamline organ procurement, potentially increasing the availability of viable liver grafts.
• It offers a potential solution for simultaneous retrieval of multiple abdominal organs, maximizing donor organ utilization.
• The findings support the viability of liver grafts procured via a simplified method, paving the way for further research and clinical application.