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[Obesity and arterial hypertension]
J A Casasnovas Lenguas1, P J Serrano Aísa, I J Ferreira Montero
1Servicio de Cardiología, Hospital Clínico Universitario Lozano Blesa, Zaragoza.
Revista Espanola De Cardiologia
|January 12, 1999
Summary
Obesity is a major public health issue linked to reduced life expectancy. This review details obesity
Area of Science:
- Endocrinology and Metabolism
- Cardiovascular Physiology
- Public Health
Context:
- Obesity affects nearly one-third of the population in developed countries, posing a significant public health challenge.
- Obesity is increasingly recognized for its complex physiopathological links with cardiovascular risk factors like diabetes, hypertension, and dyslipidemia.
Purpose:
- To elucidate the multifaceted physiopathological mechanisms underlying obesity.
- To explore the interplay between obesity and cardiovascular risk factors through hemodynamic, neurohormonal, and metabolic pathways.
Summary:
- Presents obesity's physiopathology, focusing on hemodynamic changes, neurohormonal dysregulation (sympathetic nervous system, renin-angiotensin-aldosterone system, vasopressin, endothelin), and metabolic disturbances (insulin resistance, hyperinsulinism, lipid metabolism).
- Highlights endothelial dysfunction as a key component in obesity's pathophysiology.
- Discusses the dual-principle treatment approach for obese hypertensive patients: weight management and hypertension control, considering patient-specific factors.
Impact:
- Provides a comprehensive overview of obesity's complex mechanisms, aiding in understanding its impact on cardiovascular health.
- Informs clinical practice regarding the management of obese patients, particularly those with hypertension.
- Contributes to the scientific understanding of metabolic and cardiovascular disease development.