Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neuroanatomical changes in the rat bladder after bladder outlet obstruction

R S Sutherland1, L S Baskin, B A Kogan

  • 1Urology Service, Tripler Army Medical Center, Hawaii.

British Journal of Urology
|January 12, 1999
PubMed
Summary

Partial bladder outlet obstruction in rats causes significant bladder wall changes and functional alterations. Neuropathic changes primarily affect cholinergic and adrenergic pathways, leading to detrusor instability.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Do cortical and medullary bone volume, and retromolar and ramus thickness, influence the sagittal split pattern? A retrospective analysis.

International journal of oral and maxillofacial surgery·2026
Same author

Spinal anesthesia in children: most pediatric urologists are not on board.

Journal of pediatric urology·2019
Same author

How does bone thickness affect the split pattern of sagittal ramus osteotomy?

International journal of oral and maxillofacial surgery·2019
Same author

Surprising interobserver and intra-observer variability in pediatric testicular ultrasound volumes.

Journal of pediatric urology·2019
Same author

Spinal anesthesia in children: most pediatric urologists are not on board.

Journal of pediatric urology·2019
Same author

Presence of parasite DNA in clinically unaffected nasal mucosa during cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2019

Area of Science:

  • Urology
  • Neuroscience
  • Histology

Background:

  • Partial bladder outlet obstruction (PBOO) is a common condition affecting bladder function.
  • Understanding the neuro-anatomical changes in the bladder wall following PBOO is crucial for developing effective treatments.

Purpose of the Study:

  • To investigate the histological alterations in bladder innervation after partial bladder outlet obstruction in a rat model.
  • To correlate these histological changes with functional bladder alterations.

Main Methods:

  • Partial bladder outlet obstruction was surgically induced in female rats.
  • Bladders were analyzed at 1, 2, and 4 weeks post-obstruction using morphometry and immunohistochemistry.
  • Staining for general neuronal marker PGP, acetylcholinesterase, adrenergic fibers, and nitric oxide synthase was performed.

Related Experiment Videos

Main Results:

  • Obstruction led to a 6-7 fold increase in bladder volume and weight, with smooth muscle hypertrophy.
  • Cystometry revealed increased bladder capacity and voiding pressures in obstructed rats.
  • Significant reductions in cholinergic and adrenergic neurotransmitter staining were observed in the obstructed bladder wall, while the nitric oxide pathway remained unaffected.

Conclusions:

  • Histological changes in bladder innervation, particularly in cholinergic and adrenergic pathways, are a key feature of PBOO.
  • These anatomical perturbations likely contribute to neuropathic bladder dysfunction and detrusor instability observed after outlet obstruction.