[Treatment of multi drug resistant tuberculosis]

Multi drug resistant pulmonary Tuberculosis (MDR-TB) are divided into two types. The one is primary drug resistance and the other is acquired drug resistance. Cases of acquired MDR-TB are more often. Chemotherapy of MDR-TB demands use in combination of three or more sensitive anti-tuberculosis drugs, but it is difficult to apply this combined treatment practically. In Japan, it is often effective to use in combination of sensitive anti-tuberculosis drugs added PZA, Newquinolon agents and Clarithromycin. When chemotherapy is not effective, surgical treatment should be performed. We experienced six operation cases of MDR-TB. Lobectomy were performed in five cases, and all cases were negative tuberculous bacilli after operation. One case of thoracic empyema with bronchial fistula was positive tuberculous bacilli after operation and died of MDR tuberculosis.