Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Lupus nephritis in children

J M Gloor1

  • 1Division of Nephrology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Lupus
|January 12, 1999
PubMed
Summary

Childhood lupus nephritis, a kidney complication of systemic lupus erythematosus, is more common in children than adults. Effective treatments improve survival, but long-term management requires careful attention to minimize therapy-related complications.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Five-year outcomes in living donor kidney transplants with a positive crossmatch.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2012
Same author

Intragraft gene expression in positive crossmatch kidney allografts: ongoing inflammation mediates chronic antibody-mediated injury.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2012
Same author

Terminal complement inhibition decreases antibody-mediated rejection in sensitized renal transplant recipients.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
Same author

Bilateral native ureteral ligation without nephrectomy in the management of kidney transplant recipients with native proteinuria.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2011
Same author

The histology of solitary renal allografts at 1 and 5 years after transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010
Same author

Baseline donor-specific antibody levels and outcomes in positive crossmatch kidney transplantation.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2010

Area of Science:

  • Pediatric Nephrology
  • Rheumatology
  • Immunology

Background:

  • Systemic lupus erythematosus (SLE) frequently affects the kidneys in children, presenting a spectrum of renal involvement.
  • Childhood lupus nephritis occurs more commonly than in adults and can range from mild urinalysis abnormalities to severe kidney failure.
  • Significant advancements in treatment have improved survival rates for children with lupus nephritis over the past three decades.

Purpose of the Study:

  • To review the current understanding of childhood lupus nephritis, including its clinical manifestations, treatment strategies, and long-term outcomes.
  • To highlight the effectiveness of available therapies and the challenges associated with managing this condition in pediatric patients.
  • To emphasize the importance of meticulous, long-term patient care to optimize outcomes and mitigate treatment-related morbidities.

Main Methods:

  • Review of current literature and clinical guidelines on childhood lupus nephritis.
  • Analysis of treatment protocols, including corticosteroids, cytotoxic agents, and cyclosporine.
  • Discussion of the impact of therapy on patient survival, morbidity, and psychosocial development.

Main Results:

  • Corticosteroid therapy is the primary treatment for childhood lupus nephritis.
  • Combination therapy with cytotoxic agents alongside corticosteroids enhances both short-term and long-term prognoses.
  • While survival has improved, complications such as opportunistic infections, growth disturbances, and psychosocial issues remain significant challenges.

Conclusions:

  • Effective treatments for childhood lupus nephritis have significantly improved patient survival.
  • Long-term management requires a comprehensive approach to address both the disease activity and the adverse effects of immunosuppressive therapies.
  • Optimizing patient outcomes necessitates vigilant, multidisciplinary care over extended periods to manage chronic illness and treatment complications.

Related Experiment Videos