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The application of strong cation exchange high-performance liquid chromatography to drug analysis
1Zeneca Pharmaceuticals, Macclesfield, Cheshire, UK. brian.law@alderley.zeneca.com
Journal of Pharmaceutical and Biomedical Analysis
|January 12, 1999
Abstract:
The application of strong cation exchange (SCX) HPLC to the analysis of drugs in plasma, tissue and rodent feed is presented. This approach is shown to give useful separations allowing the separation of physiochemically diverse compounds in a simple isocratic system. The SCX columns are not as robust as standard reversed-phase materials and to ensure maximum column lifetimes the use of a guard column is recommended.