Related Experiment Videos
[The influence of RS-Timolol in comparison with R-Timolol and S-Timolol on the intraocular pressure in water-loaded
K Czechowicz-Janicka1, E Kamińska, J Staszkiewicz
1Kliniki Okulistyki Centrum Medycznego Kształcenia Podyplomowego w Warszawie.
Purpose:
It is assumed that S-timolol can produce more severe systemic adverse reactions than R-timolol. The aim of this study was to estimate the intraocular pressure-lowering effect of RS-timolol in comparison to R-timolol and S-timolol in water-loaded rabbits.
Material And Methods:
Ocular hypertension was provoked in rabbits by orogastric water loading. Topical administration of one of three timolol solutions: 0.85%, RS-timolol, or 3% R-timolol, or 0.5% S-timolol was performed to the right eyes 40 min before starting the water loading procedure. Left eyes served as a control group. Intraocular pressure was measured before and 30, 60, 90, 120 min after the water loading.
Results:
Intraocular pressure-lowering effect of all three timolol solutions was comparable.
Conclusion:
RS-timolol can be effective for lowering intraocular pressure in rabbits.