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Related Experiment Videos

Cancer in ex-asbestos cement workers in Israel, 1953-1992

T H Tulchinsky1, G M Ginsberg, J Iscovich

  • 1Department of Preventive Health Services, Ministry of Health, Jerusalem, Israel.

American Journal of Industrial Medicine
|January 13, 1999
PubMed
Summary

Asbestos-cement workers experienced significantly elevated risks for mesothelioma and other cancers. Mesothelioma risk increased sharply with exposure duration, suggesting a strong link to asbestos exposure.

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Area of Science:

  • Occupational Health
  • Epidemiology
  • Environmental Health

Background:

  • Asbestos exposure is a known cause of various cancers, particularly mesothelioma.
  • Chrysotile and crocidolite asbestos fibers are used in industrial applications.
  • Long-term occupational exposure necessitates epidemiological surveillance for cancer incidence.

Purpose of the Study:

  • To investigate cancer incidence and mortality in a cohort of asbestos-cement plant workers.
  • To assess the risk of specific cancers, including mesothelioma, lung, and pleural cancers.
  • To examine the relationship between asbestos exposure duration and mesothelioma risk.

Main Methods:

  • A cohort study of 3,057 male workers in an asbestos-cement plant in Israel.
  • Follow-up period from 1953 to 1992, tracking cancer incidence and mortality.

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  • Calculation of Standardized Incidence Ratios (SIR) for various cancer types.

    • Main Results:

    • Elevated risk observed for all malignant neoplasms combined (SIR=117), lung cancer (SIR=135), mesothelioma (SIR > 5000), and unspecified pleural cancer (SIR=278).
    • Mesothelioma risk showed a steep gradient with exposure duration, increasing significantly with longer employment.
    • Atypical high ratio of mesothelioma to lung cancer cases was noted, potentially linked to high asbestos exposure and lower baseline lung cancer risk.

    Conclusions:

    • High asbestos exposure in the studied cohort led to significantly increased risks of mesothelioma and other cancers.
    • Mesothelioma risk is strongly associated with the duration of asbestos exposure.
    • The findings highlight the critical need for stringent asbestos exposure controls in occupational settings.