Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Triploidy: antenatal sonographic features with post-mortem correlation

T K Mittal1, G M Vujanić, B M Morrissey

  • 1Department of Diagnostic Radiology, University Hospital of Wales, Cardiff, U.K.

Prenatal Diagnosis
|January 13, 1999
PubMed
Summary

Triploidy in fetuses can be detected using antenatal ultrasound (US) scans, which reveal abnormalities like oligohydramnios and growth restriction. Post-mortem findings confirm these and reveal more anomalies, highlighting the need for fetal karyotyping.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IncC of broad-host-range plasmid RK2 modulates KorB transcriptional repressor activity In vivo and operator binding in vitro.

Journal of bacteriology·1999
Same author

'Listen, listen trust your own strange voice' (psychoanalytically informed conversations with a woman suffering serious illness).

Journal of advanced nursing·1999
Same author

p53 and p53-regulated genes in bladder cancer.

BJU international·1999
Same author

Angiogenesis in urological malignancy: prognostic indicator and therapeutic target.

BJU international·1999
Same author

Functional genomics in Caenorhabditis elegans: An approach involving comparisons of sequences from related nematodes.

Genome research·1999
Same author

Directed evolution of a fungal peroxidase.

Nature biotechnology·1999

Area of Science:

  • Medical imaging
  • Prenatal diagnostics
  • Genetics

Background:

  • Triploidy is a rare chromosomal abnormality with significant fetal implications.
  • Antenatal ultrasound (US) is crucial for prenatal diagnosis.
  • Accurate identification of triploidy aids in managing obstetric complications.

Purpose of the Study:

  • To compare antenatal ultrasound (US) findings with post-mortem examinations in triploid fetuses.
  • To identify key US features suggestive of triploidy.
  • To assess the diagnostic accuracy of US in detecting triploidy-related anomalies.

Main Methods:

  • Retrospective analysis of 20 triploid fetuses surviving past the first trimester.
  • Comparison of antenatal ultrasound (US) scan features with post-mortem findings.

Related Experiment Videos

  • Review of documented fetal and placental abnormalities.

    • Main Results:

    • Antenatal US scans frequently showed oligohydramnios (60%), intra-uterine growth retardation (IUGR, 55%), central nervous system (CNS) abnormalities (45%), and placental issues (55%).
    • Post-mortem confirmed US findings and revealed additional anomalies like facial dysmorphism, limb defects, and visceral system abnormalities.
    • Placental findings varied, with enlarged cystic changes (47%) and small placentas (32%) being common.

    Conclusions:

    • Triploidy should be suspected in cases of early second-trimester IUGR, oligohydramnios, major CNS abnormalities, or enlarged placentas.
    • US scan sensitivity for detecting all defects was limited by factors including oligohydramnios and equipment limitations.
    • Fetal karyotyping is recommended for confirmed triploidy diagnosis to guide obstetric management and address associated complications.