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Related Experiment Videos

Cholesterol ester transfer protein: a molecule with three faces?

C G Stevenson1

  • 1Department of Laboratory Medicine and Pathobiology, Faculty of Medicine, University of Toronto, Banting Institute, Ontario, Canada.

Critical Reviews in Clinical Laboratory Sciences
|January 14, 1999
PubMed
Summary

Cholesterol ester transfer protein (CETP) plays a complex role in atherosclerosis, acting as both a beneficial and harmful factor. Its dual function depends on metabolic context and substrate modification, making its classification challenging.

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CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienneยท2001
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Area of Science:

  • Cardiovascular Biology
  • Lipid Metabolism
  • Atherosclerosis Pathogenesis

Background:

  • Atherosclerosis pathogenesis is under intense investigation, with cholesterol ester transfer protein (CETP) emerging as a key factor.
  • CETP facilitates lipid transfer between lipoproteins, notably from HDL to apo B-containing lipoproteins.
  • CETP can also directly uptake cholesterol from cells, complicating its role.

Purpose of the Study:

  • To examine evidence for conflicting theories on CETP's role in atherosclerosis.
  • To analyze situations where CETP is proatherogenic, antiatherogenic, or both.
  • To highlight the importance of metabolic context and substrate modification in determining CETP's function.

Main Methods:

  • Review and synthesis of existing scientific literature on CETP and atherosclerosis.

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  • Analysis of studies demonstrating proatherogenic effects of CETP.
  • Examination of studies indicating antiatherogenic roles of CETP.

    • Main Results:

    • Evidence suggests CETP can promote atherosclerosis by facilitating lipid transfer to atherogenic lipoproteins.
    • Conversely, CETP may exhibit antiatherogenic properties in certain contexts.
    • The dual role of CETP is influenced by its metabolic environment and the modification of its substrates.

    Conclusions:

    • The role of CETP in atherosclerosis is context-dependent, exhibiting both pro- and antiatherogenic activities.
    • Metabolic context and substrate modification are critical, often overlooked factors in assessing CETP's impact.
    • Further research is needed to fully elucidate CETP's complex contribution to atherosclerotic disease.