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Factor V Leiden and pulmonary embolism in a young woman taking an oral contraceptive
M R DiSiena1, R Intres, D J Carter
1Department of Pathology, Berkshire Medical Center, Pittsfield, Massachusetts 01201, USA.
The American Journal of Forensic Medicine and Pathology
|January 14, 1999
Abstract:
A 34-year-old woman with a history of asthma and oral contraceptive use died suddenly. Autopsy examination showed chronic pulmonary emboli with an acute pulmonary saddle embolus. An underlying congenital thrombophilic disorder was considered. Molecular studies on DNA isolated from blood using polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis revealed coagulation factor V Leiden mutation. The incidence of venous thromboembolism in patients with factor V Leiden mutation and associated activated protein C (APC) resistance is discussed.