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Related Experiment Videos

HIV vaccine development: a subtype E-specific strategy

A E Brown1, J G McNeil

  • 1Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

The Southeast Asian Journal of Tropical Medicine and Public Health
|January 14, 1999
PubMed
Summary
This summary is machine-generated.

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Developing an HIV-1 subtype E vaccine is crucial for Southeast Asia. This research focuses on creating and testing new vaccines, including a bivalent vaccine and a live-vectored vaccine, to combat the prevalent HIV-1 subtype E epidemic.

Area of Science:

  • Immunology
  • Virology
  • Vaccinology

Background:

  • HIV/AIDS pandemic presents diverse epidemiological foci globally.
  • Subtype (clade) E infections are predominant among approximately one million HIV-infected individuals in Southeast Asia.
  • Subtype E HIV, a recombinant virus, has been epidemic in Thailand since 1989 and is increasingly prevalent across Southeast Asia.

Purpose of the Study:

  • To develop and test a subtype E-derived candidate vaccine for the Southeast Asian HIV-1 epidemic.
  • To provide a non-B clade candidate vaccine specifically designed for the local epidemic.
  • To assess vaccine-induced protection and immunologic correlates through a phase III trial.

Main Methods:

  • Development of a genotype B recombinant glycoprotein (rgp)120 candidate vaccine, tested for safety and immunogenicity in Thailand.

Related Experiment Videos

  • Production of rgp120 (E) and preparation for a phase I/II trial of a bivalent (B/E) product.
  • Development of an E-specific, live-vectored vaccine (Canarypox ALVAC constructs modified with clade E env) to augment antibody responses with CD8+ CTL responses.

    • Main Results:

    • A genotype B rgp120 vaccine candidate was found to be safe and immunogenic in a Thai population.
    • A bivalent (B/E) rgp120 vaccine is in the final stages of approval for a phase I/II trial.
    • An E-specific, live-vectored vaccine is under development to complement humoral immune responses.

    Conclusions:

    • A subtype E-derived candidate vaccine is optimal for testing vaccine concepts in Southeast Asia.
    • A collaborative consortium is developing and testing HIV vaccines tailored for the genotype E epidemic.
    • Phase III efficacy trials are essential to determine vaccine-induced protection and immunologic correlates for HIV vaccines.