Jove
Visualize
Contact Us

Related Experiment Videos

Inhibition as binding controller at the single neuron level

A K Vidybida1

  • 1Bogolyubov Institute for Theoretical Physics, Kiev, Ukraine. vidybida@bitp.kiev.ua

Bio Systems
|January 14, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Firing statistics of inhibitory neuron with delayed feedback. II: Non-Markovian behavior.

Bio Systems·2013
Same author

Firing statistics of inhibitory neuron with delayed feedback. I. Output ISI probability density.

Bio Systems·2013
Same author

Computer simulation of inhibition-dependent binding in a neural network.

Bio Systems·2003
Same author

Selectivity of chemoreceptor neuron.

Bio Systems·2001
Same author

Testing of nonlinear electrofrictiophoresis in agarose gel.

Bioelectrochemistry (Amsterdam, Netherlands)·2000
Same author

Cooperative mechanism for improving the discriminating ability in the chemoreceptor neuron binomial case.

Biological cybernetics·1999
Same journal

Ruliological Resilience: Pattern Restoration and Robustness in Wolfram Patterns. A Basis for Regeneration, Not Just in Cone Shells?

Bio Systems·2026
Same journal

The quantum-to-classical transducer: A thermodynamic and quantum mechanical framework for the emergence of bioenergetics.

Bio Systems·2026
Same journal

Forward-backward gene expression binarization for boolean state inference over a known regulatory network.

Bio Systems·2026
Same journal

Partial-label metric ceilings for evaluating gene regulatory networks inferred from single-cell foundation models.

Bio Systems·2026
Same journal

The impedance mismatch theory: A non-equilibrium thermodynamic framework for a shared energetic stress pathway in neurodegeneration.

Bio Systems·2026
Same journal

Immune signal-status misclassification: A theoretical framework for biological status assignment and failed status resolution.

Bio Systems·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Neurons integrate excitatory postsynaptic potentials (EPSP) to fire. This study shows that the timing of these EPSPs influences neuronal firing, suggesting neurons perform binding functions and use EPSPs for short-term memory.

Area of Science:

  • Computational Neuroscience
  • Neuronal Electrophysiology

Background:

  • Neurons receive natural stimuli as a sum of excitatory postsynaptic potentials (EPSP) dispersed in time.
  • Understanding how temporal summation of EPSPs affects neuronal output is crucial for deciphering neural computation.

Purpose of the Study:

  • To analyze the impact of relative timing of constituent excitatory postsynaptic potentials (EPSPs) on neuronal firing.
  • To investigate the role of inhibition in modulating neuronal responses to compound stimuli.

Main Methods:

  • Numerical solution of the Hodgkin-Huxley equations to model neuronal behavior.
  • Analysis of the triggering ability of compound stimuli based on EPSP timing.

Main Results:

  • Neuronal firing probability is dependent on the precise temporal arrangement of incoming excitatory postsynaptic potentials (EPSPs).

Related Experiment Videos

  • Inhibitory inputs act as controllers for the binding function performed by neurons receiving multiple synaptic inputs.
  • The transient dynamics of EPSPs function as an intrinsic short-term memory mechanism within a single neuron.

    • Conclusions:

    • Neurons can be viewed as performing elementary binding functions, integrating information based on synaptic input timing.
    • Inhibition plays a critical role in regulating this neuronal binding process.
    • Excitatory postsynaptic potentials (EPSPs) contribute to short-term memory at the single-neuron level.