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(S)-4C3HPG reduces infarct size after focal cerebral ischemia
C Rauca1, P Henrich-Noack, K Schäfer
1Institute of Pharmacology and Toxicology, Medical Faculty of Otto-von-Guericke University Magdeburg, Germany. ipt@uni-magdeburg.de
Neuropharmacology
|January 14, 1999
Abstract:
This study investigated whether the metabotropic glutamate receptor ligand (S)-4C3HPG can reduce brain damage after focal ischemia in rats. Application of 1 micromol of (S)-4C3HPG (intracerebroventricularly) 5 min after occlusion of the middle cerebral artery significantly reduced the infarct size by 72.3% of the saline control.