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Postprandial lipid metabolism in diabetes
N Mero1, M Syvänne, M R Taskinen
1Department of Medicine, University of Helsinki, Finland.
Atherosclerosis
|January 15, 1999
Summary
Diabetic dyslipidemia involves prolonged postprandial lipemia, characterized by increased VLDL and chylomicron remnants. This contributes to atherosclerosis and atherogenic lipoprotein subclasses in diabetic individuals.
Area of Science:
- Metabolic Disorders
- Cardiovascular Science
- Endocrinology
Background:
- Postprandial lipemia is common in diabetic dyslipidemia, even with normal fasting triglycerides.
- It involves prolonged circulation of chylomicron and VLDL remnants.
- Insulin resistance increases VLDL synthesis, exacerbating postprandial lipemia.
Purpose of the Study:
- To investigate the role and impact of postprandial lipemia in diabetic dyslipidemia.
- To understand the atherogenic potential of postprandial hypertriglyceridemia in diabetes.
Main Methods:
- Utilized apo B-48 and retinyl esters to track intestinally derived particles.
- Analyzed the relationship between postprandial lipemia and coronary artery disease in NIDDM.
- Examined the effects of postprandial hypertriglyceridemia on LDL and HDL subclasses.
Main Results:
- Increased postprandial lipemia did not predict coronary artery disease in NIDDM subjects.
- Postprandial triglyceride-rich remnants are identified as atherogenic.
- Postprandial hypertriglyceridemia promotes atherogenic changes in LDL and HDL subclasses.
Conclusions:
- Postprandial lipemia is a significant feature of diabetic dyslipidemia with atherogenic implications.
- It contributes to metabolic disturbances that increase cardiovascular risk in diabetic patients.