Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Estrogens and postprandial lipid metabolism

H E Westerveld1

  • 1Department of Internal Medicine, Academic Hospital Utrecht, The Netherlands. h.e.westerveld@digd.azu.nl

Atherosclerosis
|January 15, 1999
PubMed
Summary

Postprandial chylomicron-remnants identify women at high coronary heart disease (CAD) risk, even with normal fasting lipids. Estrogen therapy improved remnant clearance and HDL-cholesterol, potentially explaining estrogen

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A review of interprofessional training wards: Enhancing student learning and patient outcomes.

Medical teacher·2018
Same author

Cardiovascular and metabolic characteristics of infertile Chinese women with PCOS diagnosed according to the Rotterdam consensus criteria.

Reproductive biomedicine online·2010
Same author

Indicators for metabolic disturbances in anovulatory women with polycystic ovary syndrome diagnosed according to the Rotterdam consensus criteria.

Human reproduction (Oxford, England)·2008
Same author

Cardiometabolic abnormalities in the polycystic ovary syndrome: pharmacotherapeutic insights.

Pharmacology & therapeutics·2008
Same author

[Women and cardiovascular disease].

Nederlands tijdschrift voor geneeskunde·2006
Same author

Dutch medical oath.

The Netherlands journal of medicine·2005

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Lipid Metabolism

Background:

  • Coronary heart disease (CAD) risk factors in women are not fully understood, particularly within normolipidemic populations.
  • Postprandial lipid metabolism plays a crucial role in cardiovascular health, yet its specific markers for CAD risk require further investigation.
  • Estrogen's role in cardiovascular protection is partly attributed to its effects on lipid profiles.

Purpose of the Study:

  • To investigate the association between postprandial chylomicron-remnants and angiographically proven coronary heart disease (CAD) in women.
  • To determine if postprandial lipid markers can identify CAD risk in women with normal fasting triglyceride levels.
  • To evaluate the impact of 17beta-estradiol replacement therapy on postprandial lipid metabolism and HDL-cholesterol in women.

Main Methods:

  • Measurement of postprandial concentrations of small chylomicron-remnants (IDL apo B48) in women with and without angiographically proven CAD.
  • Comparison of fasting triglyceride (TG) concentrations between the two groups.
  • Assessment of changes in chylomicron-remnant clearance and HDL-cholesterol levels following 17beta-estradiol replacement therapy.

Main Results:

  • Women with CAD exhibited significantly higher postprandial concentrations of small chylomicron-remnants compared to women without CAD.
  • No significant differences in fasting TG concentrations were observed, indicating normal lipid levels in both groups.
  • 17beta-estradiol therapy led to a 41% improvement in chylomicron-remnant clearance and a 66% attenuation of postprandial HDL-cholesterol reduction.

Conclusions:

  • Postprandial concentrations of small chylomicron-remnants serve as a potential biomarker for identifying high CAD risk in normolipidemic women.
  • Estrogen replacement therapy favorably impacts postprandial lipid metabolism by enhancing remnant clearance and preserving HDL-cholesterol.
  • Improved postprandial lipid handling may contribute to the cardioprotective effects of estrogens in women.

Related Experiment Videos