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Related Experiment Videos

Apoptosis. Basic concepts and implications in coronary artery disease

P J Best1, D Hasdai, G Sangiorgi

  • 1Department of Internal Medicine and Cardiovascular Diseases of Biochemistry, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.

Arteriosclerosis, Thrombosis, and Vascular Biology
|January 15, 1999
PubMed
Summary

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Apoptosis, a regulated cell death, is implicated in coronary artery disease pathogenesis. This review covers apoptosis detection, regulation, and its role in cardiovascular disease.

Area of Science:

  • Cardiovascular Biology
  • Cell Death Mechanisms

Background:

  • Apoptosis is a distinct, regulated form of cell death.
  • Evidence suggests apoptosis contributes to coronary atherosclerotic disease, restenosis, and transplant arteriopathy.
  • Increased markers of apoptosis are observed in these conditions.

Purpose of the Study:

  • To review the detection methods for apoptosis.
  • To discuss the regulation of apoptosis by vasoactive substances.
  • To explore the role of apoptosis in coronary artery disease pathogenesis.

Main Methods:

  • Review of existing literature on apoptosis.
  • Analysis of anatomical and biochemical evidence.
  • Examination of the effects of nitric oxide and angiotensin II on vascular smooth muscle cell apoptosis.

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Main Results:

  • Apoptosis is anatomically evident in various cardiovascular conditions.
  • Vasoactive substances differentially regulate vascular smooth muscle cell apoptosis.
  • Nitric oxide may induce apoptosis, while angiotensin II may inhibit it.

Conclusions:

  • Apoptosis is a significant factor in coronary artery disease.
  • Understanding apoptosis regulation is crucial for cardiovascular disease research.
  • Further investigation into apoptosis's role in cardiovascular pathology is warranted.