Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cephalosporin-associated pseudomembranous colitis

J F Tures, W F Townsend, H D Rose

    JAMA
    |August 23, 1976
    PubMed
    Summary

    Cephalosporin antibiotics can cause diarrhea and pseudomembranous colitis. Cholestyramine resin effectively treated these antibiotic-associated gastrointestinal side effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Unsedated transnasal EGD: an alternative approach to conventional esophagogastroduodenoscopy for documenting Helicobacter pylori eradication.

    Gastrointestinal endoscopy·1999
    Same author

    Evaluation of dyspepsia and functional gastrointestinal disorders: a cost-benefit analysis of different approaches.

    European journal of gastroenterology & hepatology·1995
    Same author

    Costs of duodenal ulcer therapy with antibiotics.

    Archives of internal medicine·1995
    Same author

    Coordination of deglutition and phases of respiration: effect of aging, tachypnea, bolus volume, and chronic obstructive pulmonary disease.

    The American journal of physiology·1992
    Same author

    Preoperative testing for fecal occult blood: a questionable practice.

    The American journal of gastroenterology·1992
    Same author

    Testing for Helicobacter pylori in the diagnosis of Zollinger-Ellison syndrome.

    The American journal of gastroenterology·1991

    Area of Science:

    • Gastroenterology
    • Pharmacology
    • Infectious Diseases

    Background:

    • Antibiotic-associated diarrhea (AAD) is a common complication of antimicrobial therapy.
    • Pseudomembranous colitis (PMC) is a severe form of AAD, often linked to Clostridioides difficile infection.
    • Cephalosporins are a class of antibiotics with a known risk of gastrointestinal side effects.

    Observation:

    • A patient undergoing treatment with cephalosporin derivatives developed diarrhea and pseudomembranous colitis.
    • The patient's symptoms were directly associated with the cephalosporin therapy.

    Findings:

    • The administration of cholestyramine resin led to a rapid and complete remission of the patient's diarrhea and pseudomembranous colitis.
    • This suggests cholestyramine resin can be an effective treatment for cephalosporin-induced PMC.

    Implications:

    • Cholestyramine resin may represent a valuable therapeutic option for managing antibiotic-associated diarrhea and pseudomembranous colitis.
    • Further research into the mechanism of action and efficacy of cholestyramine in this context is warranted.
    • This case highlights the importance of considering specific antibiotic agents, like cephalosporins, as potential causes of severe gastrointestinal distress.

    Related Experiment Videos