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Updated: Jul 30, 2026
17:14
In vivo and in vitro Studies of Adaptor-clathrin Interaction
Published on: January 26, 2011
Clathrin: a good view of a shapely leg
1Department of Cell Biology, Centre of Anatomy, Medical School, Hannover Carl-Neuberg Strasse, 1 D 30625, Hannover, Germany.
Current Biology : CB
|January 16, 1999
Summary
The crystal structure of clathrin heavy chain
Area of Science:
- Structural biology
- Molecular and cell biology
Background:
- Clathrin heavy chain (CHC) is crucial for vesicle formation.
- Understanding CHC's structure informs cellular transport mechanisms.
Purpose of the Study:
- To determine the crystal structure of an amino-terminal fragment of CHC.
- To elucidate the structural basis of CHC function.
Main Methods:
- X-ray crystallography was employed to determine the protein structure.
Main Results:
- The structure revealed a globular beta-propeller domain.
- This domain is connected by an alpha-zig-zag rod to the CHC's distal segment.
Conclusions:
- The determined structure provides insights into the design of clathrin heavy chain.
- This finding advances our understanding of clathrin-mediated endocytosis.
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