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Pharmacogenomics - it's not just pharmacogenetics

D S Bailey1, A Bondar, L M Furness

  • 1Pharmacogenomics Division Incyte Europe Ltd Botanic House 100 Hills Road Cambridge CB2 1FF UK. dbailey@incyte.com.

Current Opinion in Biotechnology
|January 16, 1999
PubMed
Summary

New drug discovery technologies enhance lead optimization. Pharmacogenomics offers objective drug efficacy and safety assessments using genome-based methods.

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Area of Science:

  • Pharmacogenomics
  • Drug Discovery
  • Combinatorial Biology

Background:

  • Advancements in combinatorial chemistry and biology are expanding drug discovery possibilities.
  • Pharmacogenomics utilizes genome-based technologies to analyze drug effects.

Purpose of the Study:

  • To highlight the potential of new technologies in drug discovery and lead optimization.
  • To explain how pharmacogenomics can objectively measure drug efficacy and adverse effects.

Main Methods:

  • Leveraging genome-based technologies.
  • Measuring dynamic properties of pharmacological systems.

Main Results:

  • New technologies enable novel approaches to drug discovery and lead optimization.
  • Pharmacogenomics provides an objective assessment of drug biological efficacy.
  • Pharmacogenomics identifies potential adverse drug effects.

Conclusions:

  • Combinatorial technologies and pharmacogenomics are revolutionizing drug development.
  • Objective efficacy and safety data can be obtained through pharmacogenomic approaches.

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