Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intracellular detection assays for high-throughput screening

J E González1, P A Negulescu

  • 1Aurora Biosciences Corp 11010 Torreyana Road San Diego CA 92121 USA.

Current Opinion in Biotechnology
|January 16, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Desmoid tumor: Clinical analysis and literature review.

Revista de gastroenterologia de Mexico (English)·2025
Same author

The antihypertensive and diuretic effect of crude root extract and saponins from Solanum sisymbriifolium Lam., in L-NAME-induced hypertension in rats.

Journal of ethnopharmacology·2022
Same author

Erratum: Azimuthal Anisotropy at the Relativistic Heavy Ion Collider: The First and Fourth Harmonics [Phys. Rev. Lett. 92, 062301 (2004)].

Physical review letters·2021
Same author

Uncertainty calculation methods in dose assessment for dicentric chromosome assay.

International journal of radiation biology·2020
Same author

A note on Poisson goodness-of-fit tests for ionizing radiation induced chromosomal aberration samples.

International journal of radiation biology·2018
Same author

The Latin American Biological Dosimetry Network (LBDNet).

Radiation protection dosimetry·2016

New optical assay methods using fluorescent or luminescent read-outs accelerate drug discovery screening with living cells. Genetically encoded probes enable custom biosensors for diverse biological targets and interactions.

Area of Science:

  • Biotechnology
  • Pharmacology
  • Cell Biology

Background:

  • Drug discovery relies on efficient screening methods.
  • Living cell assays offer physiological relevance.
  • Existing methods have limitations in target scope and customization.

Purpose of the Study:

  • To introduce novel optical assay methods for drug discovery.
  • To highlight the utility of fluorescent and luminescent read-outs.
  • To explore the potential of genetically encoded probes.

Main Methods:

  • Development of new optical assay techniques.
  • Utilizing fluorescent and luminescent detection systems.
  • Employing genetically encoded probes for biosensing.

Related Experiment Videos

Main Results:

  • Optical assays accelerate cell-based drug screening.
  • Methods are applicable to various targets like receptors and enzymes.
  • Genetically encoded probes allow for custom biosensor development.

Conclusions:

  • Optical assay methods enhance drug discovery efficiency.
  • These techniques support a broad range of biological targets.
  • Customizable biosensors expand possibilities for studying complex cellular processes.