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Immunocytochemical demonstration of reduced glutathione in neurons of rat forebrain
L Maybodi1, D V Pow, V N Kharazia
1Department of Cell Biology and Anatomy, University of North Carolina, CB 7090, Chapel Hill, NC 27599, USA.
Brain Research
|January 16, 1999
Abstract:
Histochemical studies show reduced glutathione (GSH) in neuroglia, whereas immunocytochemistry of glutaraldehyde-fixed tissue reveals GSH also in neurons. Using an antibody suitable for formaldehyde-fixed tissue, we find GSH staining in the cytoplasm of neurons throughout the brain. Staining was prominent in large pyramidal neurons of cerebral cortex, in basal ganglia, and in reticular and ventrobasal thalamic nuclei.