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[Nutmeg--more than a spice]

M Pytte1, T Rygnestad

  • 1Avdeling for legemidler, Regionsykehuset i Trondheim.

Tidsskrift for Den Norske Laegeforening : Tidsskrift for Praktisk Medicin, Ny Raekke
|January 16, 1999
PubMed
Summary

Nutmeg poisoning, though rare, can occur due to its psychotropic volatile oils, myristicin and elemicin. This case highlights the first reported instance in Norway, emphasizing potential anticholinergic and amphetamine-like effects.

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Area of Science:

  • Toxicology
  • Pharmacology
  • Ethnobotany

Background:

  • Nutmeg (Myristica fragrans) is a common spice with a history of traditional use for its psychoactive properties.
  • Published cases of nutmeg poisoning, some fatal, underscore its potential toxicity.

Observation:

  • This report details the first documented case of nutmeg poisoning in Norway.
  • The patient's symptoms were consistent with anticholinergic and psychotropic effects.

Findings:

  • The primary toxic constituents are believed to be volatile oils, notably myristicin and elemicin.
  • These compounds are metabolized into substances with amphetamine-like properties.
  • Nutmeg's psychotropic effects stem from these active ingredients.

Implications:

  • This case expands the geographical understanding of nutmeg toxicity.
  • It reinforces the need for awareness regarding the potential dangers of consuming large quantities of nutmeg.
  • Further research into the metabolic pathways and precise mechanisms of nutmeg toxicity is warranted.

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