[The EAA-ergic modulation of the brain dopaminergic system as a basis for creating new nootropic agents with...

The paper provides theoretical evidence for and practical confirmation of the possible use of three lipophilic derivatives of N-acetyl-aspartic acid (EAA-AKF-94; AKF-92-10, and PIR-87-6-0). These compounds were shown to display pronounced nootropic activity to correct behavioral, memory, and cognitive disorders in rats exposed to emotional stress. Evidence is provided for the fact that modulation of monoaminergic brain activity mediated by heterosynaptic activation of EAA receptors.