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Updated: Aug 6, 2026

Quantifying Cognitive Decrements Caused by Cranial Radiotherapy
Published on: October 18, 2011
[Conditioned reflex activity in rats after chronic antenatal gamma irradiation in association with mercazolyl]
L N Pavlova1, O S Izmest'eva, L P Zhavoronkov
1Medical Radiological Research Center, Russian Academy of Medical Science, Obninsk.
Abstract:
The purpose of investigation is the study of combined influence of gamma-radiation (137Cs, 1.25 Gy during 20 days) and mercazolyl (20 mg/100 ml drinkable water) in utero on the intellectual state of rats in the postnatal ontogenesis. It was shown, that antenatal separate influence both of gamma-radiation and mercazolyl induced the delay of intellectual development in 2 and 7 months age. The combined influence of these factors induced essential increase observed effect. There is a party of the conditioned reflex activity in 7 month age.

