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Myoglobin function evaluated in working heart tissue

J D Gardner1, R W Schubert

  • 1Biomedical Engineering Department, Louisiana Tech University, Ruston, Louisiana 71272-0046, USA. jgardner@engr.latech.edu

Advances in Experimental Medicine and Biology
|January 16, 1999
PubMed
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Myoglobin does not significantly aid oxygen transport in working heart tissue. Optimized models show myoglobin diffusion is not elevated, suggesting limited facilitation of oxygen diffusion in steady-state conditions.

Area of Science:

  • Physiology
  • Biophysics
  • Computational Biology

Background:

  • Myoglobin's role in oxygen transport is debated, especially in working heart muscle.
  • Previous models using literature values for myoglobin diffusion showed minimal facilitation.
  • Muscle contraction may influence oxygen diffusion, potentially augmenting myoglobin's role.

Purpose of the Study:

  • To investigate elevated diffusion coefficients for oxygen and myoglobin in working heart tissue.
  • To model oxygen transport using the Radially-Averaged, Axially-Distributed (RAAD) model.
  • To determine if myoglobin significantly facilitates oxygen diffusion in the heart.

Main Methods:

  • Utilized the RAAD model, incorporating axial diffusion, myoglobin facilitation, and Michaelis-Menten oxygen consumption.

Related Experiment Videos

  • Employed a variable-mesh finite-difference scheme for numerical solutions.
  • Optimized model parameters using a Nelder-Mead simplex routine to minimize error between predicted and experimental pO2 data.

    • Main Results:

    • Myoglobin facilitation had minimal impact on predicted oxygen distribution.
    • Optimized oxygen diffusion coefficients remained elevated.
    • Optimized myoglobin diffusion coefficients were lower than experimentally measured values.

    Conclusions:

    • Myoglobin does not significantly facilitate oxygen diffusion to tissue in the steady state.
    • Myoglobin diffusion is not elevated in working heart tissue.
    • Contractile mechanisms do not appear to augment myoglobin-facilitated oxygen transport in this model.