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[Experimental studies on pramiverine (author's transl)]

C J Morel

    Arzneimittel-Forschung
    |April 1, 1976
    PubMed
    Summary
    This summary is machine-generated.

    Pramiverine demonstrated a preventive effect on experimental gastric ulcers in rats. In patients, it significantly reduced gastric secretion and motility, aiding in diagnosis and evaluating surgical vagotomy.

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    Area of Science:

    • Pharmacology
    • Gastroenterology
    • Experimental Medicine

    Background:

    • Gastric ulcers and duodenal ulcers are common gastrointestinal conditions.
    • Surgical vagotomy is a treatment option for some ulcer patients.
    • Accurate diagnosis and assessment of treatment efficacy are crucial.

    Purpose of the Study:

    • To evaluate the preventive effect of 4,4-diphenyl-N-isopropyl-cyclohexylamine-hydrochloride (pramiverine) on experimental gastric ulcers.
    • To assess pramiverine's impact on gastric secretion and motility in patients with duodenal ulcers.
    • To determine pramiverine's utility in radiological diagnosis of the duodenum and jejunum.

    Main Methods:

    • Experimental induction of gastric ulcers in rats.
    • Clinical study involving 14 patients with duodenal ulcers.

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  • Measurement of maximally stimulated gastric secretion.
  • Electromyographic examinations of stomach and duodenum.
  • Hypotensive duodenography.

    • Main Results:

    • Pramiverine showed a preventive effect on experimental gastric ulcers in rats.
    • A 50% reduction in maximally stimulated gastric secretion was observed in patients with duodenal ulcers.
    • Pramiverine decreased spontaneous and induced pressure waves in the stomach and duodenum.
    • Prolonged reduction of motility by pramiverine facilitated excellent radiological diagnosis.

    Conclusions:

    • Pramiverine exhibits preventive properties against gastric ulcers.
    • Pramiverine effectively reduces gastric secretion and motility in duodenal ulcer patients.
    • Pramiverine can serve as a reliable criterion for evaluating surgical vagotomy.
    • Pramiverine enhances diagnostic accuracy in duodenography and jejunography.