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Supraventricular arrhythmia: a complication of 5-fluorouracil therapy
S A Aziz1, N A Tramboo, K Mohi-ud-Din
1Sheri Kashmir Institute of Medical Sciences, Srinagar, India.
Clinical Oncology (Royal College of Radiologists (Great Britain))
|January 16, 1999
Abstract:
5-Fluorouracil is an S-phase-specific, synthetic pyrimidine antimetabolite, which is used as a cytostatic agent for a variety of malignant lesions, either singly or in multidrug regimens. Gastrointestinal toxicity and myelosuppression are the most common adverse reactions, but, of late, clinical cardiotoxicity has been reported in both prospective and retrospective studies. We present our experience of clinical cardiotoxicity in five patients.