Selected coagulation disorders associated with cancer

The association between cancer and the increased tendency for bleeding and clotting is well established. Many investigators have reported on the interaction between tumor-related and plasma-related factors that may be responsible for this predisposition in cancer patients. The precise role of any of these factors in thrombosis or bleeding remains speculative. A good understanding of the course of the underlying malignancy, mechanisms of actions of the agents used for treatment, and a high degree of clinical suspicion are required to direct practicing physicians towards an objective and timely diagnosis of these complications. The goal of this article is to provide a broad overview of a few important hemostatic problems encountered in cancer patients.